Uji Aktivitas Antiinflamasi Infusa Saussurea costus pada Mencit Galur DDY

Nindi Fathina Alfani, Dhigna Luthfiyani Citra Pradana, Hany Yusmaini, Kristina Simanjuntak

Abstract


Abstrak. Inflamasi merupakan respon yang kompleks dari tubuh terhadap adanya cedera maupun infeksi yang ditandai dengan ciri yaitu, edema, eritema, rasa panas, timbul rasa nyeri, serta kehilangan fungsi. Tanaman kayu india (Saussurea costus) merupakan salah satu tanaman obat yang memiliki aktivitas antiinflamasi. Penelitian ini dilakukan untuk mengetahui pengaruh aktivitas antiinflamasi infusa kayu india (Saussurea costus) pada hewan uji mencit galur DDY dengan metode carrageenan-induced paw edema. Sampel sebanyak 30 mencit putih jantan dengan berat 20-30 gram, terdiri atas: (1) kelompok kontrol positif, (2) kelompok kontrol negatif, (3) kelompok dosis 42 mg/kgBB, (4) kelompok dosis 56 mg/kgBB, dan (5) kelompok dosis 70 mg/kgBB. Penelitian ini ditinjau dari penurunan ketebalan udema telapak kaki mencit. Pengukuran ketebalan udema dilakukan dengan menggunakan jangka sorong yang dilakukan setiap jam selama 3 jam setelah diinduksi karagenan. Berdasarkan hasil pengujian, didapatkan dosis 70 mg/kgBB merupakan dosis yang paling efektif dan stabil dalam menghambat pembentukan udema dengan persentase inhibisi udema sebesar 66.1% pada jam ketiga. Hasil uji Kruskal-wallis menunjukkan bahwa terdapat efek antiinflamasi terhadap udema pada telapak kaki mencit galur DDY (p = 0.025), hal ini disebabkan karena kayu india (Saussurea costus) mengandung terpenoid yang diketahui memiliki aktivitas antiinflamasi. Berdasarkan hal tersebut, dapat disimpulkan bahwa infusa kayu india (Saussurea costus) memiliki potensi sebagai antiinflamasi.


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Ruang Jurnal Lantai 2, Gedung Cipto Mangunkusumo, Fakultas Kedokteran, UPN Veteran Jakarta, Indonesia.

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