Perbandingan Pemberian Obat Seftriakson dan Levofloksasin Terhadap Kadar Kreatinin Serum Pasien Pneumonia Rawat Inap di RS Citra Sari Husada Karawang Tahun 2017 - 2018

Abstract

Pneumonia is a disease that occurs throughout the world with the most common cases in young children and pre-elderly people. Pneumonia can be caused by Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa. Therefore ceftriaxone and levofloxacin antibiotic therapy may be given, with a side effects of nephrotoxicity. Nephrotoxicity can be seen from the increase in creatinine levels prior and following the administration of ceftriaxone and levofloxacin. This study aims to determine the comparison of ceftriaxone and levofloxacin drugs to serum creatinine levels in hospitalized patients with pneumonia at Citra Sari Husada Hospital, Karawang, 2017-2018. This research is analytic observational study with cross-sectional design. The research samples taken from medical data records of hospitalized pneumonia patients in the 45-59 years group age with purposive sampling method at Citra Sari Husada Hospital, Karawang. The study sample size is 68 with the shortest 5 days and the longest 13 days in hospital. Mann-Whitney U test results found no significant differences between ceftriaxone and levofloxacin administration compared to serum creatinine levels of pneumonia patient's. The conclusion of this study suggest that there are no significant differences between ceftriaxone and levofloxacin drugs administration against serum creatinine levels of hospitalized pneumonia patients at Citra Sari Husada Hospital, Karawang in 2017-2018.