HUBUNGAN PROTEIN KLOTHO (α-KLOTHO) DENGAN STADIUM PENYAKIT GAGAL GINJAL KRONIK SEBUAH SYSTEMATIC REVIEW
Abstract
Latar Belakang : Gagal Ginjal Kronik merupakan suatu penyakit degeneratif yang terjadi pada organ ginjal, dimana ginjal gagal dalam menjalankan fungsi filtrasi dan reabsorpsi cairan tubuh, yang ditandai dengan penurunan nilai LFG, proteinuria, dan peningkatan urea dan kreatinin pada sedimen urin. Beberapa penelitian telah membahas mengenai α-klotho dan perannya pada mekanisme sistem organ seperti genitourinaria dan kardiovaskular. Pada beberapa penelitian tersebut, telah ditemukan beberapa bukti mengenai peran α-klotho dalam PGK dan progresinya, serta peluang α-klotho untuk menjadi biomarker PGK. Penelitian ini bertujuan untuk mengumpulkan penemuan-penemuan pada penelitian mengenai hubungan antara α-klotho dan stadium PGK, serta mengulas mengenai α-klotho dan perannya pada stadium PGK. Metode: Systematic Review dengan melakukan pencarian literatur menggunakan pangkalan data PubMed dan Science Direct. Literatur yang membahas mengenai PGK, α-klotho, dan asosiasi. Hasil: Terdapat 4 penelitian yang memaparkan gambaran kadar α-klotho pada setiap stadium PGK, dengan penemuan terdapatnya penurunan kadar α-klotho seiring dengan peningkatan stadium PGK. Didapatkan 3 penelitian yang menemukan bahwa terdapat hubungan bermakna antara α-klotho dengan stadium PGK dan eLFG. Kesimpulan: Terdapat hubungan yang bermakna antara α-klotho dengan stadium PGK.
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